Has a College Football game ever ended 82-28?
Exactly once. On October 15, 1988, Houston beat Tulsa 82-28, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 82-28 in league history.
That makes 82-28 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 83-28 has happened never and 82-29 has happened never.