Has a College Football game ever ended 85-3?
Exactly once. On October 5, 1912, LSU beat Louisiana 85-3, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 85-3 in league history.
That makes 85-3 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 86-3 has happened never and 85-4 has happened never.