Has a College Football game ever ended 95-21?
Exactly once. On October 21, 1989, Houston beat SMU 95-21, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 95-21 in league history.
That makes 95-21 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 96-21 has happened never and 95-22 has happened never.