Has an NFL game ever ended 21-19?
Yes. NFL has seen a final score of 21-19 30 times. It first happened on September 25, 1960, when New York Giants beat San Francisco 49ers, and most recently on November 16, 2025, when Los Angeles Rams beat Seattle Seahawks.
That makes 21-19 the 181st most common final score out of 1,095 that have ever occurred in NFL. One point away, 22-19 has happened 21 times and 21-20 has happened 73 times.