Has an NFL game ever ended 22-19?
It has. 22-19 has been a NFL final 21 times in 18,234 games. The first was Chicago Cardinals beat Oorang Indians on December 2, 1923; the latest was Los Angeles Chargers beat Philadelphia Eagles on December 8, 2025.
That makes 22-19 the 241st most common final score out of 1,095 that have ever occurred in NFL. One point away, 23-19 has happened 22 times and 22-20 has happened 18 times. At one point the score disappeared for 46 years, between 1923 and 1969.