Has an NFL game ever ended 41-10?
It has. 41-10 has been a NFL final 37 times in 18,236 games. The first was Chicago Bears beat Green Bay Packers on September 22, 1940; the latest was Baltimore Ravens beat Denver Broncos on November 3, 2024.
That makes 41-10 the 152nd most common final score out of 1,090 that have ever occurred in NFL. One point away, 42-10 has happened 20 times and 41-11 has happened never.