Has an NFL game ever ended 42-10?
Yes. NFL has seen a final score of 42-10 20 times. It first happened on October 25, 1936, when Green Bay Packers beat Pittsburgh Pirates, and most recently on December 28, 2025, when New England Patriots beat New York Jets.
That makes 42-10 the 256th most common final score out of 1,095 that have ever occurred in NFL. One point away, 43-10 has happened 1 times and 42-11 has happened never.