Has an NFL game ever ended 42-21?
Yes. NFL has seen a final score of 42-21 25 times. It first happened on October 10, 1948, when Chicago Bears beat Los Angeles Rams, and most recently on December 8, 2024, when Minnesota Vikings beat Atlanta Falcons.
That makes 42-21 the 206th most common final score out of 1,095 that have ever occurred in NFL. One point away, 43-21 has happened 3 times and 42-22 has happened 1 times.