Has an NFL game ever ended 45-2?

Exactly once. On December 5, 1953, Los Angeles Rams beat Baltimore Colts 45-2, and no NFL game before or since has ended that way. When it happened it was a scorigami, the first 45-2 in league history.

Where 45-2 sits among nearby NFL scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 45-2 the 838th most common final score out of 1,090 that have ever occurred in NFL. One point away, 46-2 has happened never and 45-3 has happened 12 times.

Every 45-2 in NFL history

Date	Result	Season
1953-12-05	Los Angeles Rams over Baltimore Colts	1953

Open the NFL grid at 45-2