Has an NFL game ever ended 49-6?
Yes. NFL has seen a final score of 49-6 2 times. It first happened on December 13, 1964, when Kansas City Chiefs beat San Diego Chargers, and most recently on December 7, 1969, when New York Giants beat St. Louis Cardinals.
That makes 49-6 the 723rd most common final score out of 1,095 that have ever occurred in NFL. One point away, 50-6 has happened never and 49-7 has happened 6 times.
Every 49-6 in NFL history
| Date | Result | Season | |
|---|---|---|---|
| 1969-12-07 | New York Giants over St. Louis Cardinals | 1969 | |
| 1964-12-13 | Kansas City Chiefs over San Diego Chargers | 1964 |