Has an NFL game ever ended 52-21?
It has. 52-21 has been a NFL final 10 times in 18,236 games. The first was Chicago Bears beat Chicago Cardinals on December 11, 1949; the latest was Detroit Lions beat Chicago Bears on September 14, 2025.
That makes 52-21 the 376th most common final score out of 1,090 that have ever occurred in NFL. One point away, 53-21 has happened never and 52-22 has happened never.
Every 52-21 in NFL history
| Date | Result | Season | |
|---|---|---|---|
| 2025-09-14 | Detroit Lions over Chicago Bears | 2025 | |
| 2018-11-08 | Pittsburgh Steelers over Carolina Panthers | 2018 | |
| 2008-12-28 | San Diego Chargers over Denver Broncos | 2008 | |
| 1986-12-21 | Cincinnati Bengals over New York Jets | 1986 | |
| 1984-12-16 | Cincinnati Bengals over Buffalo Bills | 1984 | |
| 1966-10-30 | Dallas Cowboys over Pittsburgh Steelers | 1966 | |
| 1965-11-28 | Kansas City Chiefs over Houston Oilers | 1965 | |
| 1963-12-08 | Kansas City Chiefs over Denver Broncos | 1963 | |
| 1961-10-22 | Boston Patriots over Buffalo Bills | 1961 | |
| 1949-12-11 | Chicago Bears over Chicago Cardinals | 1949 |