Has an NFL game ever ended 65-24?

Exactly once. On October 29, 1950, Los Angeles Rams beat Detroit Lions 65-24, and no NFL game before or since has ended that way. When it happened it was a scorigami, the first 65-24 in league history.

Where 65-24 sits among nearby NFL scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 65-24 the 840th most common final score out of 1,095 that have ever occurred in NFL. One point away, 66-24 has happened never and 65-25 has happened never.

Every 65-24 in NFL history

Date	Result	Season
1950-10-29	Los Angeles Rams over Detroit Lions	1950

Open the NFL grid at 65-24