Has a Copa America game ever ended 12-0?
Yes. Copa America has seen a final score of 12-0 2 times. It first happened on January 22, 1942, when Argentina beat Ecuador, and most recently on January 22, 1942, when Argentina beat Ecuador.
That makes 12-0 the 26th most common final score out of 36 that have ever occurred in Copa America. One point away, 13-0 has happened never and 12-1 has happened never.