Has a Copa America game ever ended 8-1?
Yes. Copa America has seen a final score of 8-1 2 times. It first happened on March 1, 1953, when Brazil beat Bolivia, and most recently on March 1, 1953, when Brazil beat Bolivia.
That makes 8-1 the 26th most common final score out of 36 that have ever occurred in Copa America. One point away, 9-1 has happened 4 times and 8-2 has happened 2 times.