Has an AFL game ever ended 110-42?
Exactly once. On April 19, 1958, Melbourne beat Geelong 110-42, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 110-42 in league history.
That makes 110-42 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 111-42 has happened 2 times and 110-43 has happened 2 times.