Has an AFL game ever ended 110-43?
Yes. AFL has seen a final score of 110-43 2 times. It first happened on July 13, 1929, when Carlton beat Footscray, and most recently on May 6, 2012, when Carlton beat GWS.
That makes 110-43 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 111-43 has happened 1 times and 110-44 has happened never. At one point the score disappeared for 83 years, between 1929 and 2012.