Has an AFL game ever ended 110-54?
Yes. AFL has seen a final score of 110-54 5 times. It first happened on July 19, 1952, when Geelong beat Melbourne, and most recently on June 28, 1997, when Geelong beat Adelaide.
That makes 110-54 the 633rd most common final score out of 6,649 that have ever occurred in AFL. One point away, 111-54 has happened 2 times and 110-55 has happened 1 times. At one point the score disappeared for 28 years, between 1958 and 1986.