Has an AFL game ever ended 125-41?
Exactly once. On July 11, 1925, Fitzroy beat Hawthorn 125-41, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 125-41 in league history.
That makes 125-41 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 126-41 has happened never and 125-42 has happened 1 times.