Has an AFL game ever ended 125-42?
Exactly once. On September 10, 2021, Melbourne beat Geelong 125-42, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 125-42 in league history.
That makes 125-42 the 3884th most common final score out of 6,649 that have ever occurred in AFL. One point away, 126-42 has happened never and 125-43 has happened 1 times.