Has an AFL game ever ended 125-49?
Exactly once. On July 31, 1915, Fitzroy beat Richmond 125-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 125-49 in league history.
That makes 125-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 126-49 has happened never and 125-50 has happened 1 times.