Has an AFL game ever ended 151-43?
Exactly once. On June 10, 2016, Hawthorn beat Essendon 151-43, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 151-43 in league history.
That makes 151-43 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 152-43 has happened never and 151-44 has happened never.