Has an AFL game ever ended 151-46?
Exactly once. On August 5, 2018, GWS beat Carlton 151-46, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 151-46 in league history.
That makes 151-46 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 152-46 has happened never and 151-47 has happened 1 times.