Has an AFL game ever ended 161-53?
Exactly once. On May 2, 2010, Geelong beat Richmond 161-53, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 161-53 in league history.
That makes 161-53 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 162-53 has happened never and 161-54 has happened 1 times.