Has an AFL game ever ended 161-54?
Exactly once. On June 14, 1992, Footscray beat Melbourne 161-54, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 161-54 in league history.
That makes 161-54 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 162-54 has happened never and 161-55 has happened never.