Has an AFL game ever ended 45-16?
Exactly once. On September 10, 1898, Fitzroy beat Essendon 45-16, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 45-16 in league history.
That makes 45-16 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 46-16 has happened never and 45-17 has happened never.