Has an AFL game ever ended 45-19?
Yes. AFL has seen a final score of 45-19 2 times. It first happened on May 24, 1899, when Melbourne beat Carlton, and most recently on August 11, 1900, when Carlton beat Sydney.
That makes 45-19 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 46-19 has happened never and 45-20 has happened never.