Has an AFL game ever ended 46-12?
Exactly once. On June 2, 1900, Fitzroy beat Geelong 46-12, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 46-12 in league history.
That makes 46-12 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 47-12 has happened never and 46-13 has happened never.