Has an AFL game ever ended 46-18?
Yes. AFL has seen a final score of 46-18 2 times. It first happened on July 24, 1897, when Melbourne beat Carlton, and most recently on May 31, 1919, when St Kilda beat Geelong.
That makes 46-18 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 47-18 has happened never and 46-19 has happened never.