Has an AFL game ever ended 46-25?
Exactly once. On August 26, 1911, Essendon beat Fitzroy 46-25, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 46-25 in league history.
That makes 46-25 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 47-25 has happened never and 46-26 has happened 2 times.