Has an AFL game ever ended 48-19?
Exactly once. On August 2, 1913, Sydney beat Melbourne 48-19, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 48-19 in league history.
That makes 48-19 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 49-19 has happened never and 48-20 has happened never.