Has an AFL game ever ended 48-22?
Exactly once. On May 2, 1908, Carlton beat St Kilda 48-22, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 48-22 in league history.
That makes 48-22 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 49-22 has happened never and 48-23 has happened 5 times.