Has an AFL game ever ended 49-25?
Exactly once. On July 7, 1906, Carlton beat St Kilda 49-25, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 49-25 in league history.
That makes 49-25 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 50-25 has happened never and 49-26 has happened never.