Has an AFL game ever ended 49-28?
Exactly once. On July 14, 1900, Carlton beat St Kilda 49-28, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 49-28 in league history.
That makes 49-28 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 50-28 has happened never and 49-29 has happened 1 times.