Has an AFL game ever ended 50-17?
Exactly once. On April 25, 1968, Essendon beat Carlton 50-17, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 50-17 in league history.
That makes 50-17 the 3884th most common final score out of 6,649 that have ever occurred in AFL. One point away, 51-17 has happened never and 50-18 has happened never.