Has an AFL game ever ended 53-15?
Exactly once. On June 30, 1900, Fitzroy beat Carlton 53-15, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 53-15 in league history.
That makes 53-15 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 54-15 has happened never and 53-16 has happened 1 times.