Has an AFL game ever ended 53-16?
Exactly once. On May 24, 1898, Fitzroy beat St Kilda 53-16, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 53-16 in league history.
That makes 53-16 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 54-16 has happened 1 times and 53-17 has happened never.