Has an AFL game ever ended 53-26?
Exactly once. On July 10, 1897, Melbourne beat Fitzroy 53-26, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 53-26 in league history.
That makes 53-26 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 54-26 has happened never and 53-27 has happened never.