Has an AFL game ever ended 80-37?
Exactly once. On September 9, 1905, Fitzroy beat Essendon 80-37, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-37 in league history.
That makes 80-37 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-37 has happened 4 times and 80-38 has happened 1 times.