Has an AFL game ever ended 80-38?
Exactly once. On May 11, 1957, Essendon beat Footscray 80-38, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-38 in league history.
That makes 80-38 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-38 has happened 1 times and 80-39 has happened never.