Has an AFL game ever ended 80-41?
Exactly once. On August 25, 1917, Carlton beat Richmond 80-41, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-41 in league history.
That makes 80-41 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-41 has happened 2 times and 80-42 has happened 4 times.