Has an AFL game ever ended 80-42?
It has. 80-42 has been a AFL final 4 times in 16,622 games. The first was Essendon beat Geelong on May 12, 1906; the latest was Melbourne beat Hawthorn on June 30, 1956.
That makes 80-42 the 947th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-42 has happened never and 80-43 has happened 3 times.