Has an AFL game ever ended 80-48?
Exactly once. On May 21, 2022, Richmond beat Essendon 80-48, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-48 in league history.
That makes 80-48 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-48 has happened 2 times and 80-49 has happened 4 times.