Has an AFL game ever ended 80-49?
Yes. AFL has seen a final score of 80-49 4 times. It first happened on May 17, 1919, when Richmond beat Melbourne, and most recently on October 9, 2020, when Richmond beat St Kilda.
That makes 80-49 the 947th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-49 has happened 4 times and 80-50 has happened 2 times. At one point the score disappeared for 56 years, between 1963 and 2019.