Has an MLB game ever ended 16-11?
Yes. MLB has seen a final score of 16-11 26 times. It first happened on June 3, 1876, when St. Louis Brown Stockings beat Philadelphia Athletics, and most recently on April 29, 2023, when San Diego Padres beat San Francisco Giants.
That makes 16-11 the 163rd most common final score out of 330 that have ever occurred in MLB. One point away, 17-11 has happened 20 times and 16-12 has happened 28 times.