Has an NCAA Men's Basketball game ever ended 121-52?

Exactly once. On November 23, 2010, Saint Mary's Gaels beat Chicago State Cougars 121-52, and no NCAA Men's Basketball game before or since has ended that way. When it happened it was a scorigami, the first 121-52 in league history.

Where 121-52 sits among nearby NCAA Men's Basketball scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 121-52 the 3013th most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 122-52 has happened never and 121-53 has happened never.

Every 121-52 in NCAA Men's Basketball history

Date	Result	Season
2010-11-23	Saint Mary's Gaels over Chicago State Cougars	2011

Open the NCAA Men's Basketball grid at 121-52