Has a College Football game ever ended 66-19?
Exactly once. On December 3, 2005, USC beat UCLA 66-19, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 66-19 in league history.
That makes 66-19 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 67-19 has happened never and 66-20 has happened 1 times.