Has a College Football game ever ended 66-20?
Exactly once. On September 8, 2024, Clemson beat App State 66-20, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 66-20 in league history.
That makes 66-20 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 67-20 has happened 1 times and 66-21 has happened 10 times.