Has an NFL game ever ended 16-6?
Yes. NFL has seen a final score of 16-6 34 times. It first happened on October 24, 1926, when Hartford Blues beat Brooklyn Lions, and most recently on November 24, 2024, when Seattle Seahawks beat Arizona Cardinals.
That makes 16-6 the 167th most common final score out of 1,095 that have ever occurred in NFL. One point away, 17-6 has happened 64 times and 16-7 has happened 42 times. At one point the score disappeared for 35 years, between 1929 and 1964.