Has an NFL game ever ended 43-22?
Exactly once. On January 11, 2014, New England Patriots beat Indianapolis Colts 43-22, and no NFL game before or since has ended that way. When it happened it was a scorigami, the first 43-22 in league history.
That makes 43-22 the 840th most common final score out of 1,095 that have ever occurred in NFL. One point away, 44-22 has happened 4 times and 43-23 has happened 3 times.
Every 43-22 in NFL history
| Date | Result | Season | |
|---|---|---|---|
| 2014-01-11 | New England Patriots over Indianapolis Colts | 2013 | Playoff |