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Has an NFL game ever ended 45-21?

It has. 45-21 has been a NFL final 28 times in 18,341 games. The first was Chicago Cardinals beat Detroit Lions on September 28, 1947; the latest was Detroit Lions beat Arizona Cardinals on October 11, 2026.

Where 45-21 sits among nearby NFL scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 45-21 the 189th most common final score out of 1,092 that have ever occurred in NFL. One point away, 46-21 has happened 2 times and 45-22 has happened 1 times.

Every 45-21 in NFL history

DateResultSeason
2026-10-11Detroit Lions over Arizona Cardinals2026
2025-12-21Cincinnati Bengals over Miami Dolphins2025
2017-11-13Carolina Panthers over Miami Dolphins2017
2014-11-30Houston Texans over Tennessee Titans2014
2014-11-10Philadelphia Eagles over Carolina Panthers2014
2013-10-27Denver Broncos over Washington Redskins2013
2006-11-26Indianapolis Colts over Philadelphia Eagles2006
1994-09-04Indianapolis Colts over Houston Oilers1994
1993-11-14San Francisco 49ers over Tampa Bay Buccaneers1993
1988-10-02Cincinnati Bengals over Los Angeles Raiders1988
1972-12-17Denver Broncos over New England Patriots1972
1972-10-08New York Giants over New Orleans Saints1972
1970-11-22Dallas Cowboys over Washington Redskins1970
1965-10-17San Francisco 49ers over Los Angeles Rams1965
1964-11-29Green Bay Packers over Dallas Cowboys1964
1962-12-02Dallas Cowboys over Cleveland Browns1962
1961-11-05Baltimore Colts over Green Bay Packers1961
1959-12-06Detroit Lions over Chicago Cardinals1959
1952-12-07Detroit Lions over Chicago Bears1952
1951-12-09Chicago Bears over New York Yanks1951
1951-11-11Los Angeles Rams over Chicago Cardinals1951
1950-12-10Cleveland Browns over Washington Redskins1950
1950-12-03Detroit Lions over Baltimore Colts1950
1949-11-20Detroit Lions over New York Giants1949
1948-12-12Philadelphia Eagles over Detroit Lions1948
1947-12-07Chicago Cardinals over Philadelphia Eagles1947
1947-11-23Washington Redskins over Chicago Cardinals1947
1947-09-28Chicago Cardinals over Detroit Lions1947
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Open the NFL grid at 45-21